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Presynaptic Dopaminergic Deficits in Lesch-Nyhan Disease NEJM 334:1568-1572, 16021996., Ernst,M.,et al, 1996 See this aricle in Pubmed Article Abstract The fluorodopa F 18 ratio was significantly lower in the putamen(31 percent of control values),caudate nucleus(39 percent),frontal cortex(44 percent),and ventral tegmental complex(substantia nigra and ventral tegmentum;57 percent)in the patients with Lesch-Nyhan disease than in the controls.Uptake of the tracer was abnormally low even in the youngest patients tested,and there was no overlap in the values between patients and controls.Patients with Lesch-Nyhan disease have abnormally few dopaminergic nerve terminals and cell bodies.The abnormality involves all dopaminergic pathways and is not restricted to the basal ganglia.These dopaminergic deficits are pervasive and appear to be developmental in origin,which suggests that they contribute to the characteristic neuropsychiatric manifestations of the disease.

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(click to filter results - removes previous filter) basal ganglia,lesion of CAT scan,emission CAT scan,emission,abnormal dopamine genetic neurologic disorders Lesch-Nyhan syndrome neurotransmitter

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